Apr 04, 2013 · The dentate gyrus (DG) hippocampal region is one of the most plastic regions in the mammalian brain, exemplified by its ability to generate adult-born principal neurons that integrate into the pre-existing network.Cited by: 110. This study assessed the role of melatonin in modulating running wheel(RW)-induced hippocampal neurogenesis in adult C3H/HeN mice. Chronic melatonin (0.02 mg/mL, oral for 12 days) treatment did not affect cell proliferation or cell survival determined by the number of BrdU-positive cells in dentate gyrus of mice with access to fixed wheel (FW).Cited by: 61.
Many different mRNAs and proteins are selectively expressed in the dentate gyrus, and the dentate gyrus is a site of adult neurogenesis; that is, new neurons are continually generated in the adult dentate gyrus. To investigate mRNA and protein expression specific to . The dentate gyrus (DG), an important part of the hippocampus, plays a critical role in consolidation of information from short-term to long-term memory, and also in spatial navigation. Neural stem/progenitor cells (NSPCs) exist throughout life in the subgranular zone (SGZ) of the DG, where they develop into granular cells and establish synaptic connections with nearby cells.Author: Lei Zhang, Xinhua Zhang.
Oct 15, 2013 · The dentate gyrus (DG) is a critical component of the hippocampal circuit involved in episodic and spatial memory. The DG contains granule cells (DGCs) that receive excitatory input from the entorhinal cortex (EC) via the perforant pathway and send excitatory mossy fiber projections to the CA3 region. Because of its unique electrophysiologic characteristics and connectivity, the DG may play a Cited by: 16. Adult neurogenesis is the process by which neurons are generated from neural stem cells in the adult. This process is different from the embryonic development of neurogenesis.. In most mammals, new neurons are continually born throughout adulthood in two regions of the brain: The subgranular zone (SGZ), part of the dentate gyrus of the hippocampus, where neural stem cells give birth to granule.
May 10, 2019 · What is the role of adult neurogenesis in learning, memory, and mood? Luna et al. found that adult-born neurons either inhibited or excited the dentate gyrus, depending on whether synaptic inputs originated from the lateral or the medial entorhinal cortex (see the Perspective by Llorens-Martín). These opposing mechanisms were driven by extrasynaptic transmission from adult-born neurons Cited by: 4. Introduction. Several thousand new dentate granule cells (DGCs) are generated in the adult brain daily (Altman and Das, 1965, Cameron and McKay, 2001).However, less than half of these newborn DGCs integrate into the pre-existing dentate gyrus circuit and participate in hippocampal functioning (Kempermann et al., 1997, Gu et al., 2012, Sahay et al., 2011, Nakashiba et al., 2012, Kirschen et al Author: Jia Shen, Depeng Wang, Xinxing Wang, Shashank Gupta, Bhargav Ayloo, Song Wu, Paras Prasad, Qiaojie X.